CAMPSQ487
Title : Defensin NP-1 - rat
GenInfo Identifier : 483220
Source : Rattus norvegicus [Rat]
Taxonomy : Animalia, Mammals
UniProt: Q62716
PubMed : 2543629
Activity : Antibacterial, Antifungal
Gram Nature : Gram +ve, Gram -ve
Target :
S. aureus 502A [18 h] ( MIC <100 cfu/ml) , E. coli ML-35 [18 h] ( MIC < 100 cfu/ml ) , C. albicans 820 [18 h] ( MIC < 100 cfu/ml ) ,C. neoformans A-383 [18 h] ( MIC = 1.7 x 102 cfu/ml)
Validated : Experimentally validated
Pfam : PF00323 : Defensin_1 ( Mammalian defensin )
PF00879 : Defensin_propep ( Defensin propeptide )
InterPro : IPR016327 : Alpha-defensin.
IPR006080 : Defensin_beta/neutrophil.
IPR002366 : Defensin_propep.
IPR006081 : Mammalian_defensins.
AMP Family : Defensin
Signature :
ID Type Pattern / HMM
DefensinH32_11 HMM
Gene Ontology :
GO ID Ontology Definition
Evidence
GO:0005615 Cellular component Extracellular space IBA
GO:0019731 Biological process Antibacterial humoral response IBA
GO:0061844 Biological process Antimicrobial humoral immune response mediated by antimicrobial peptide IBA
GO:0071222 Biological process Cellular response to lipopolysaccharide IBA
GO:0050832 Biological process Defense response to fungus IEA
GO:0050829 Biological process Defense response to Gram-negative bacterium IBA
GO:0050830 Biological process Defense response to Gram-positive bacterium IBA
GO:0002227 Biological process Innate immune response in mucosa IBA
GO:0031640 Biological process Killing of cells of other organism IEA
GO:0051673 Biological process Membrane disruption in other organism IBA
Length : 32
Sequence:
 VTCYCRRTRCGFRERLSGACGYRGRIYRLCCR

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