CAMPSQ460
Title : Lactotransferrin precursor
GenInfo Identifier : 418131
Source : Bos taurus [Bovine]
Taxonomy : Animalia, Mammals
UniProt: P24627
PDB: 1BLF, 1LFC, 1NKX, 1SDX, 1Y58, 2ALU, 2AYS, 2B65, 2DOJ, 2DP8, 2DQV, 2DS9, 2DSF, 2DVC, 2DWA, 2DWH, 2DWI, 2DWJ, 2DXR, 2DXY, 2DYX, 2E0S, 2E1S, 2FA7, 2G93, 2H4I, 2HCA, 2NUV, 2NWJ, 2O1L, 2O51, 2OCU, 2P1S, 2PX1, 2Q8J, 2QJE, 2R71, 2R9J, 2ZMB, 3CFL, 3CI8, 3CRB, 3E9X, 3IAZ, 3IB0, 3IB1, 3IB2, 3K0V, 3KJ7, 3MJN, 3O97,
Structure Database : CAMPST487, CAMPST639, CAMPST541, CAMPST554, CAMPST558
PubMed : 9521752 , 8980754
Activity : Antibacterial
Gram Nature : Gram +ve, Gram -ve
Target :
E.coli ( MIC = 12.5microg/ml)
Validated : Experimentally validated
Pfam : PF00405 : Transferrin ( Transferrin )
InterPro : IPR016357 : Transferrin.
IPR001156 : Transferrin_fam.
IPR018195 : Transferrin_Fe_BS.
AMP Family : Transferrin
Signature :
ID Type Pattern / HMM
TransferrinP_4 Pattern W-Q-x(0,1)-R-x(0,1)-M-[KR]-K-[LV]
TransferrinH_4 HMM
Gene Ontology :
GO ID Ontology Definition
Evidence
GO:0009986 Cellular component Cell surface IEA
GO:0005769 Cellular component Early endosome IBA
GO:0005615 Cellular component Extracellular space IDA
GO:0005886 Cellular component Plasma membrane IBA
GO:0032991 Cellular component Protein-containing complex IEA
GO:0055037 Cellular component Recycling endosome IBA
GO:0042581 Cellular component Specific granule ISS
GO:0004869 Molecular function Cysteine-type endopeptidase inhibitor activity IDA
GO:0008201 Molecular function Heparin binding IEA
GO:0005506 Molecular function Iron ion binding IEA
GO:0001530 Molecular function Lipopolysaccharide binding IEA
GO:0043539 Molecular function Protein serine/threonine kinase activator activity IEA
GO:0004252 Molecular function Serine-type endopeptidase activity IEA
GO:0005102 Molecular function Signaling receptor binding IMP
GO:0019731 Biological process Antibacterial humoral response IDA
GO:0019732 Biological process Antifungal humoral response ISS
GO:0061844 Biological process Antimicrobial humoral immune response mediated by antimicrobial peptide IEA
GO:0060349 Biological process Bone morphogenesis ISS
GO:0050829 Biological process Defense response to Gram-negative bacterium IEA
GO:0002227 Biological process Innate immune response in mucosa ISS
GO:0055072 Biological process Iron ion homeostasis IEA
GO:0006826 Biological process Iron ion transport IBA
GO:0031640 Biological process Killing of cells of other organism IEA
GO:0051673 Biological process Membrane disruption in other organism IEA
GO:0044793 Biological process Negative regulation by host of viral process IEA
GO:0043066 Biological process Negative regulation of apoptotic process IDA
GO:0032780 Biological process Negative regulation of ATPase activity IEA
GO:2000117 Biological process Negative regulation of cysteine-type endopeptidase activity IDA
GO:0031665 Biological process Negative regulation of lipopolysaccharide-mediated signaling pathway ISS
GO:2001205 Biological process Negative regulation of osteoclast development IDA
GO:1900229 Biological process Negative regulation of single-species biofilm formation in or on host organism ISS
GO:2000308 Biological process Negative regulation of tumor necrosis factor (ligand) superfamily member 11 production IDA
GO:0045071 Biological process Negative regulation of viral genome replication IEA
GO:0001503 Biological process Ossification IEA
GO:1900159 Biological process Positive regulation of bone mineralization involved in bone maturation IDA
GO:1902732 Biological process Positive regulation of chondrocyte proliferation ISS
GO:0043123 Biological process Positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
GO:0051092 Biological process Positive regulation of NF-kappaB transcription factor activity IEA
GO:0045669 Biological process Positive regulation of osteoblast differentiation ISS
GO:0033690 Biological process Positive regulation of osteoblast proliferation IDA
GO:0034145 Biological process Positive regulation of toll-like receptor 4 signaling pathway IEA
GO:0001817 Biological process Regulation of cytokine production ISS
GO:0032680 Biological process Regulation of tumor necrosis factor production ISS
GO:0009986 Cellular component Cell surface IEA
GO:0005769 Cellular component Early endosome IBA
GO:0005615 Cellular component Extracellular space IDA
GO:0005886 Cellular component Plasma membrane IBA
GO:0032991 Cellular component Protein-containing complex IEA
GO:0055037 Cellular component Recycling endosome IBA
GO:0042581 Cellular component Specific granule ISS
GO:0004869 Molecular function Cysteine-type endopeptidase inhibitor activity IDA
GO:0008201 Molecular function Heparin binding IEA
GO:0005506 Molecular function Iron ion binding IEA
GO:0001530 Molecular function Lipopolysaccharide binding IEA
GO:0043539 Molecular function Protein serine/threonine kinase activator activity IEA
GO:0004252 Molecular function Serine-type endopeptidase activity IEA
GO:0005102 Molecular function Signaling receptor binding IMP
GO:0019731 Biological process Antibacterial humoral response IDA
GO:0019732 Biological process Antifungal humoral response ISS
GO:0061844 Biological process Antimicrobial humoral immune response mediated by antimicrobial peptide IEA
GO:0060349 Biological process Bone morphogenesis ISS
GO:0050829 Biological process Defense response to Gram-negative bacterium IEA
GO:0002227 Biological process Innate immune response in mucosa ISS
GO:0055072 Biological process Iron ion homeostasis IEA
GO:0006826 Biological process Iron ion transport IBA
GO:0031640 Biological process Killing of cells of another organism IEA
GO:0051673 Biological process Membrane disruption in another organism IEA
GO:0044793 Biological process Negative regulation by host of viral process IEA
GO:0043066 Biological process Negative regulation of apoptotic process IDA
GO:0032780 Biological process Negative regulation of ATP-dependent activity IEA
GO:0031665 Biological process Negative regulation of lipopolysaccharide-mediated signaling pathway ISS
GO:0045071 Biological process Negative regulation of viral genome replication IEA
GO:0001503 Biological process Ossification IEA
GO:0043123 Biological process Positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
GO:0051092 Biological process Positive regulation of NF-kappaB transcription factor activity IEA
GO:0045669 Biological process Positive regulation of osteoblast differentiation ISS
GO:0033690 Biological process Positive regulation of osteoblast proliferation IDA
GO:0034145 Biological process Positive regulation of toll-like receptor 4 signaling pathway IEA
GO:0006508 Biological process Proteolysis IEA
GO:0001817 Biological process Regulation of cytokine production ISS
GO:0032680 Biological process Regulation of tumor necrosis factor production ISS
Length : 25
Sequence:
 FKCRRWQWRMKKLGAPSITCVRRAF

| © 2022, Biomedical Informatics Centre, ICMR-NIRRCH |
ICMR-National Institute for Research in Reproductive and Child Health, Jehangir Merwanji Street, Parel, Mumbai-400012
Maharashtra, India