CAMPSQ4
Title : Hepcidin-20
GenInfo Identifier : 10863973
Source : Homo sapiens [Human]
Taxonomy : Animalia, Mammals
UniProt: P81172
PDB: 1M4E, 1M4F, 2KEF, 3H0T
Structure Database : CAMPST37, CAMPST38, CAMPST170, CAMPST263
PubMed : 11113131
Activity : Antibacterial, Antifungal
Gram Nature : Gram +ve, Gram -ve
Target :
E.coli ML35p, S. epidermidis, S. aureus, C. albicans, group B Streptococcus
Validated : Experimentally validated
Comment : Inactive against Pseudomonas aeruginosa
Pfam : PF06446 : Hepcidin ( Hepcidin )
InterPro : IPR010500 : Hepcidin.
AMP Family : Hepcidin
Signature :
ID Type Pattern / HMM
HepcidinH20_4 HMM
HepcidinH_22 HMM
HepcidinP20_4 Pattern C-x-[FW]-C-C-x-C-C-x(4,5)-C
Gene Ontology :
GO ID Ontology Definition
Evidence
GO:0045179 Cellular component Apical cortex IEA
GO:0005576 Cellular component Extracellular region NAS
GO:0005615 Cellular component Extracellular space IDA
GO:0014704 Cellular component Intercalated disc IEA
GO:0005634 Cellular component Nucleus IEA
GO:0005507 Molecular function Copper ion binding IEA
GO:0005179 Molecular function Hormone activity IDA
GO:0097690 Molecular function Iron ion transmembrane transporter inhibitor activity IDA
GO:0005102 Molecular function Signaling receptor binding IPI
GO:0006953 Biological process Acute-phase response IEA
GO:0007568 Biological process Aging IEA
GO:0061844 Biological process Antimicrobial humoral immune response mediated by antimicrobial peptide IDA
GO:0006879 Biological process Cellular iron ion homeostasis IDA
GO:1903413 Biological process Cellular response to bile acid IEA
GO:0071354 Biological process Cellular response to interleukin-6 IEA
GO:0071222 Biological process Cellular response to lipopolysaccharide IEA
GO:0071356 Biological process Cellular response to tumor necrosis factor IEA
GO:0071481 Biological process Cellular response to X-ray IEA
GO:0042742 Biological process Defense response to bacterium IBA
GO:0050832 Biological process Defense response to fungus IDA
GO:0050829 Biological process Defense response to Gram-negative bacterium IDA
GO:0050830 Biological process Defense response to Gram-positive bacterium IDA
GO:0006955 Biological process Immune response TAS
GO:0031640 Biological process Killing of cells of other organism IDA
GO:0097421 Biological process Liver regeneration IEA
GO:0060586 Biological process Multicellular organismal iron ion homeostasis IMP
GO:0002262 Biological process Myeloid cell homeostasis IEA
GO:0045779 Biological process Negative regulation of bone resorption IEA
GO:0050728 Biological process Negative regulation of inflammatory response IEA
GO:1904479 Biological process Negative regulation of intestinal absorption IMP
GO:0032413 Biological process Negative regulation of ion transmembrane transporter activity IDA
GO:1904039 Biological process Negative regulation of iron export across plasma membrane IDA
GO:0034760 Biological process Negative regulation of iron ion transmembrane transport IBA
GO:1904255 Biological process Negative regulation of iron ion transmembrane transporter activity IDA
GO:0000122 Biological process Negative regulation of transcription by RNA polymerase II ISS
GO:0061051 Biological process Positive regulation of cell growth involved in cardiac muscle cell development IEA
GO:1903364 Biological process Positive regulation of cellular protein catabolic process IEA
GO:0043032 Biological process Positive regulation of macrophage activation IEA
GO:1902916 Biological process Positive regulation of protein polyubiquitination IDA
GO:2000646 Biological process Positive regulation of receptor catabolic process IDA
GO:0002092 Biological process Positive regulation of receptor internalization IDA
GO:0045944 Biological process Positive regulation of transcription by RNA polymerase II IEA
GO:0007259 Biological process Receptor signaling pathway via JAK-STAT IEA
GO:0036017 Biological process Response to erythropoietin IEA
GO:0045471 Biological process Response to ethanol IEA
GO:0010039 Biological process Response to iron ion IMP
GO:1990641 Biological process Response to iron ion starvation IEA
GO:0033189 Biological process Response to vitamin A IEA
GO:0010043 Biological process Response to zinc ion IEA
Length : 20
Sequence:
 ICIFCCGCCHRSKCGMCCKT

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