CAMPSQ375
Title : Ruminococcin-A
GenInfo Identifier : 38257917
Source : Ruminococcus gnavus
Taxonomy : Monera
UniProt: P83674
PubMed : 11526013
Activity : Antibacterial
Gram Nature : Gram +ve
Target :
Bacteroides vulgatus ATCC 8482 ( MIC =600 microg/ml), Bifidobacterium adolescentis ATCC 15703 ( MIC =150 microg/ml), Bifidobacterium breve ATCC 15700 ( MIC =300 microg/ml), Bifidobacterium catenulatum ATCC 27539 ( MIC =150 microg/ml), B. longum ATCC 15707 ( MIC =75 microg/ml), Eubacterium contortum ATCC 25540 ( MIC =32.5 microg/ml), Ruminococcus obeum ATCC 29174 ( MIC =32.5 microg/ml), R. torques ATCC 27756 ( MIC =300 microg/ml), R. gnavus ATCC 29149 ( MIC =75 microg/ml), C. nexile ATCC 27757 ( MIC =150 microg/ml), C. oroticum ATCC 13619 ( MIC =600 microg/ml), C. perfringens CpA ( MIC =75 microg/ml), C. difficile serogroup A B-1 ( MIC =75 microg/ml), C. difficile serogroup C C253 ( MIC =75 microg/ml), C. difficile serogroup D ATCC 43598 ( MIC =150 microg/ml), C. difficile serogroup F M-1 ( MIC =150 microg/ml), C. difficile serogroup S3 79685 ( MIC =75 microg/ml), C. difficile ATCC 43255 ( MIC =150 microg/ml), C. botulinum type A CIP 38 ( MIC =75 microg/ml), C. botulinum type BNCTC 7273 ( MIC =75 microg/ml), C. botulinum type E NCTC 8266 ( MIC =75 microg/ml), C. sordellii VPI 9048 ( MIC =150 microg/ml), C. bifermentans NCTC 506 ( MIC =75 microg/ml), C. septicum ATCC 12464 ( MIC =150 microg/ml), C. sporogenes ATCC 19404 ( MIC =300 microg/ml), B. cereus Z4222, TZ415 ( MIC =75 microg/ml), B. cereus Z4234, K1231, P2101 ( MIC =150 microg/ml)
Validated : Experimentally validated
Comment : Inactive against B. cereus K1166, L2104, P2174, Z421, P21S , Enterococcus faecalis CIP 76117 , Bacteroides fragilis ATCC 25285 , Bacteroides thetaiotaomicron ATCC 29148 , Bacteroides putredenis ATCC 29800
Pfam : PF04604 : L_biotic_typeA ( Type-A lantibiotic )
InterPro : IPR007682 : Lantibiotic_typ-A.
AMP Family : Bacteriocin
Signature :
ID Type Pattern / HMM
BacteriocinH27_7 HMM
Gene Ontology :
GO ID Ontology Definition
Evidence
GO:0005576 Cellular component Extracellular region IDA
GO:0005102 Molecular function Signaling receptor binding IEA
GO:0019835 Biological process Cytolysis IEA
GO:0050830 Biological process Defense response to Gram-positive bacterium IDA
GO:0006965 Biological process Positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria IDA
Length : 21
Sequence:
GNGVLKTISHECNMNTWQFLF

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